Nuclear Magnetic Resonance Identification of Military Nerve Agents and Related Compounds by Two-dimensional P-h Heteronuclear Overhauser Effect Spectroscopy

Disclaimer The findings in this report are not to be construed as an official Department of the Army position unless so designated by other authorizing documents. Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathenng and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense. Respondents should be aware that notwithstanding any other provision of law. no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. Triethylphosphate and two diastereoisomers of Opinacolyl methylphosphonic acid, the primary hydrolysis product of the nerve agent soman, were identified in an organic solvent with a single 'P-'H heteronuclear Overhauser effect spectroscopy (HOESY) spectrum correlating phosphorus nuclei to their ./-coupled protons. An analogous heteronuclear multiple bond correlation experiment is also presented to demonstrate the superiority of HOESY for detecting long-range 3l P-'H pairs. This superiority results from two features specific to the HOESY technique, its reliance on the transfer of phase coherence through conformational space, and its direct detection of P nuclei.